When the brains of Wistar rats were extracted 11]4 hours after single intraperitoneal injections of radio-active imipramine some desmethylimipramine (DMI) was always found, together with comparable amounts of iminodibenzyi (IdB) and 2 hydroxyimipramine. The total radioactivity recovered from brain,
Metabolism of ingested14C-triolein
✍ Scribed by Niels Thorsgaard Pedersen; Jørgen Marqversen
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 281 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0340-6997
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Following oral administration of DL-[14C]prenylamine, about 40% of the dose administered was excreted in urine within 10 days. Less than 0.1% of the dose was excreted as unchanged prenylamine. The drug was extensively metabolized to at least 20 to 25 metabolites. The structure of 12 metabolites coul
## Abstract The rate of ^14^CO~2~ production from 2‐^14^C‐5‐FU was measured in rats bearing the Novikoff ascites hepatoma. Tracer amounts were injected and ^14^CO~2~ collected over a 6‐hour period. As the tumor cells proliferated the rate of 2‐^14^C‐5‐FU oxidation decreased markedly over the approx