𝔖 Bobbio Scriptorium
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Metabolism of high doses of cyclophosphamide

✍ Scribed by Robert A. V. Milsted; Michael Jarman

Publisher
Springer
Year
1982
Tongue
English
Weight
216 KB
Volume
8
Category
Article
ISSN
0344-5704

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πŸ“œ SIMILAR VOLUMES

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The in vivo activation of cyclophosphamide (Endoxan) to cytostatic and alkylating metabolites has been studied. Endoxan is metabolized to the weak anion by microsomal dealkylation in the rat's liver; this product is the first alkylating metabolite. About 80% of the alkylating activity of the serum,

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The outcome for patients with pineoblastoma has historically been very poor, with most patients dying of disseminated disease despite irradiation. Furthermore, the low incidence of this tumor has hindered progress toward defining better treatment strategies. Here we report the activity and toxicity