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Metabolism of exogenous arachidonic acid by polymorphonuclear leukocytes from psoriatic patients

✍ Scribed by J. Solá; L. Vila; L. Puig; J. M. Moragas

Book ID
104745513
Publisher
Springer-Verlag
Year
1991
Tongue
English
Weight
444 KB
Volume
283
Category
Article
ISSN
0340-3696

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✦ Synopsis

We evaluated the metabolism of exogenous arachidonic acid in polymorphonuclear leukocytes from psoriatic patients in comparison with those from normal subjects. The leukocytes were incubated with 10 microM labelled arachidonic acid and 5 microM A23187 for varying periods of time. We evaluated all the compounds derived from the 5-lipoxygenase activity, including the products of non-enzymatic transformation of leukotriene A4 and w-oxidized leukotriene B4. In the experimental conditions used, there was no significant difference in the formation of any compound at any time of incubation. These results indicate that there is no intrinsic alteration either in 5-lipoxygenase activity or in w-oxidation ability of circulating polymorphonuclear leukocytes in psoriatic patients.

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The chemokinetic response of psoriatic and normal polymorphonuclear leukocytes to arachidonic acid lipoxygenase products
✍ F. M. Cunningham; E. Wong; P. M. Woollard; M. W. Greaves 📂 Article 📅 1986 🏛 Springer-Verlag 🌐 English ⚖ 338 KB

Polymorphonuclear leukocytes (PMN) from ten patients with chronic stable plaque psoriasis, five of whom had more than 40% skin involvement and five with less than 20% involvement, responded in a dose-related fashion to stimulation with the arachidonic acid lipoxygenase products 5- and 12-hydroxyeico