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Metabolism of doxorubicin and epirubicin in adult human hepatocytes in culture

✍ Scribed by F. Ballet; J. Robert; M.E. Bouma; P. Vrignaud; R. Infante


Book ID
113199576
Publisher
Elsevier Science
Year
1986
Weight
254 KB
Volume
18
Category
Article
ISSN
0031-6989

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The pharmacokinetics of doxorubicin (DOX), iodo-doxorubicin (I-DOX) and their metabolites in plasma has been examined in five patients each receiving 50 mg/m2 of both anthracyclines as a bolus injection. Terminal half-life, mean residence time (MRT), peak plasma concentration Cmax, and area under th