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Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog and monkey

✍ Scribed by William R. Michael; William R. King; J.M. Wakim

Book ID
119001474
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
929 KB
Volume
21
Category
Article
ISSN
0041-008X

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πŸ“œ SIMILAR VOLUMES

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## Abstract Systemic treatment with disodium ethane‐hydroxy‐1, 1‐diphosphonate is ineffective in inhibiting the calcergenic reactions induced in mouse skin by the lanthanides. In contrast, disodium dichloromethylene diphosphonate prevents lanthanide calcergy induced by 12 of the 15 compounds tested

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Both disodium pyrophosphate and disodium ethane-hydroxy-1, 1-diphosphate inhibit the reaction of simple calcergy induced in the mouse by lead acetate. The pyrophosphate is effective only by a direct interaction with the lead salt and the disphosphonate is effective only before the occurrence of hist