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Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A

✍ Scribed by SALPHATI, LAURENT

Book ID
121256981
Publisher
Informa plc
Year
1999
Tongue
English
Weight
404 KB
Volume
29
Category
Article
ISSN
0049-8254

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The metabolism and covalent binding of 14 C-monocrotaline in Sprague-Dawley (SD) rat liver microsomes was investigated using the inducers dexamethasone, clotrimazole, pregnenolone-16␣-carbonitrile, and phenobarbital. Monocrotaline is a pyrrolizidine alkaloid (PA) that causes a syndrome in rats that