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Metabolism of coumarin by human P450s: A molecular modelling study

✍ Scribed by David F.V. Lewis; Yuko Ito; Brian G. Lake

Book ID
116919352
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
260 KB
Volume
20
Category
Article
ISSN
0887-2333

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## Abstract The kinetic analysis of coumarin oxidation by CYP2A6 suggested that substrate binding and release occurred in the multiple steps and such events proceeded rapidly. However, the crystal structure of the CYP2A6‐coumarin complex reveals that no obvious channel is open enough to allow couma