A m c t I J TLC and liquid scintillation spectrometry were used to determine the identities and relative quantities of aspirin and its metabolites in the gastric juice, blood plasma, rumen (nonglandular portion), and corpus (glandular portion) of the rat stomach 4 min. after the oral administration of aspirin-7-1.C.
It was found that aspirin and salicylic acid are the major components in the gastric juice, blood plasma, and rumen and corpus tissues. Trace levels of a compound with an R, value corresponding to that of salicyluric acid was found in the fluids and tissues analyzed. No glucuronide conjugates of salicylic acid or polyhydroxy metabolites of aspirin were found. The level of salicylic acid was fourfold higher in the corpus tissue than in the rumen tissue.
Keyphrases 0 Aspirin, radiolabeled-metabolism in rumen and corpus tissues, during first 4 min. after oral administration, rats, TLC and liquid scintillation spectrometric determination of metabolites 0 Salicylic aciddetermination as metabolite in rumen and corpus tissues of rat 4 min. after oral administration of radiolabeled aspirin 0 Metabolism-radiolabeled aspirin, determination of metabolites in rat 4 min. after oral administration, rumen and corpus tissues * Holtman Rat Co.. Madison. Wis. f Abbot Laboratones. North Chicago. Ill. * Brinkmann Instruments Co., Westbury. N. Y.