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Metabolism of arylhydrazines by cytochrome P-450 mixed function oxidases and prostaglandin(H)synthase from mouse lungs

โœ Scribed by Lawson, Terence


Book ID
122745369
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
496 KB
Volume
34
Category
Article
ISSN
0304-3835

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In sensitised guinea-pig lungs alterations in leukotriene (LT) metabolism occurred which resulted in an increase in LTD4 synthesis and a reduction in its catabolism. This may lead to an increase in the concentration of this potent spasmogen in the sensitised lungs. The LTs may cause hyperreactivity