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Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites

✍ Scribed by Mark Rosolowsky; J.R. Falck; William B. Campbell


Book ID
115741659
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
759 KB
Volume
1300
Category
Article
ISSN
0005-2760

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The purpose of the present study was to determine the effect of the n-6 fatty acid, dihomogammalinolenic acid (DGLA, 20 : 3, n-6) on arachidonic acid (AA) (C20:4) metabolism by human peripheral mononuclear leukocytes (HPML). After incubation of HPML with A23187 (5 ~tM) and DGLA, the cyclooxygenase (