Metabolism of a potential 8-aminoquinoline antileishmanial drug in rat liver microsomes
β Scribed by Anthony D. Theoharides; Chung Ho; Hector Velazquez
- Book ID
- 115778068
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 870 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0006-2952
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WR6026 is an 8-aminoquinoline analog of primaquine that is being developed for the treatment of visceral leishmaniasis and Pneumocystis carinii pneumonia. These studies examined the oral toxicity in Sprague-Dawley rats and Beagle dogs when administered daily for 13 weeks. A 13 week recovery period w
Postmortem changes in the drug-metabolizing enzymes in rat liver microsome were studied. Parameters investigated were: microsomal protein, NADPH-cytochrome P-450 reductase activity, NADH-cytochrome b5 reductase activity, cytochrome b5 content, cytochrome P-450 content, aminopyrine N-demethylase acti