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Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines

✍ Scribed by Burgey, Christopher S.; Robinson, Kyle A.; Lyle, Terry A.; Sanderson, Philip E. J.; Lewis, S. Dale; Lucas, Bobby J.; Krueger, Julie A.; Singh, Rominder; Miller-Stein, Cynthia; White, Rebecca B.; Wong, Bradley; Lyle, Elizabeth A.; Williams, Peter D.; Coburn, Craig A.; Dorsey, Bruce D.; Barrow, James C.; Stranieri, Maria T.; Holahan, Marie A.; Sitko, Gary R.; Cook, Jacquelynn J.; McMasters, Daniel R.; McDonough, Colleen M.; Sanders, William M.; Wallace, Audrey A.; Clayton, Franklin C.; Bohn, Dennis; Leonard, Yvonne M.; Detwiler,, Theodore J.; Lynch,, Joseph J.; Yan, Youwei; Chen, Zhongguo; Kuo, Lawrence; Gardell, Stephen J.; Shafer, Jules A.; Vacca, Joseph P.

Book ID: 119957454
Publisher: American Chemical Society
Year: 2003
Tongue: English
Weight: 340 KB
Volume: 46
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm020311f

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