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Metabolism and pharmacokinetics of the N- and C-n-octyl analogues of pyridoglutethimide [3-ethyl-3-(4-pyridyl)piperidine-2, 6-dione]: novel inhibitors of aromatase

✍ Scribed by Alison Seago; Michael H. Baker; John Houghton; Leung Chui-Sheung; Michael Jarman

Book ID: 115779733
Publisher: Elsevier Science
Year: 1987
Tongue: English
Weight: 544 KB
Volume: 36
Category: Article
ISSN: 0006-2952
DOI: 10.1016/0006-2952(87)90372-8

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## Abstract Reaction of isonicotinic [^14^C] acid hydrazide (**1**) with the Zinke salt (**2**) afforded N‐(4‐pyridyl [^14^C] carbonylimino)pyridinium ylide (**3**) in 81% chemical yield. Sodium borohydride reduction of **3** gave N‐(4‐pyridyl [^14^C] carbonylamino) −1,2,3,6‐tetrahydropyridine (**4