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Metabolism and pharmacokinetics of prostaglandin E1administered by intravenous infusion in human subjects

✍ Scribed by W. Cawello; H. Schweer; R. Müller; R. Bonn; H. W. Seyberth

Publisher
Springer
Year
1994
Tongue
English
Weight
292 KB
Volume
46
Category
Article
ISSN
0031-6970

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✍ T. Taylor; L. F. Chasseaud; E. Doyle; A. Darragh; D. A. O'Kelly; D. Fitzgerald 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 391 KB 👁 2 views

## Abstract Plasma concentrations of isosorbide dinitrate have been measured after intravenous infusion of drug at a rate of 5·0 mg h^−1^ for 150 min and after single equal oral doses of 12·5 mg of drug in solution to two normal human subjects. During the infusion, uneven plateau concentrations wer