Metabolism and mutagenicity of acrylonitrile: An in vivo study
β Scribed by Lambotte-Vandepaer, M. ;Duverger-van Bogaert, M. ;Rollmann, B.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1985
- Weight
- 507 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0192-2521
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## Abstract Organs consist of several types of cells with specialized functions. This cellular localization of function is often referred to as compartmentation. Due to the intrinsic low sensitivity of MR methods it is generally not possible __in vivo__ to obtain images or spectra of single cells.
Alclofenac (A) and two of its metabolites, dihydroxyalclofenac (DHA) and alclofenac epoxide (AE), were tested for their mutagenic potential. Alclofenac and DHA showed no mutagenic, transforming or clastogenic potential in any in vitro experiment. The addition of a supplementary metabolic activation