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Metabolism and excretion of 2-nitro-p-cresol in rats

✍ Scribed by Hideo Kurebayashi; Seiichi Nambaru; Masamichi Fukuoka; Tsutomu Yamaha; Akira Tanaka


Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
229 KB
Volume
76
Category
Article
ISSN
0340-5761

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Salicylic phenolic glucuronide is excreted rapidly by apparent first-order kinetics (t>a about 0.7 hr.) after intravenous administration to adult rats. Only a small fraction of an injected dose is hydrolyzed in vim to salicylic acid. The glucuronide is apparently not absorbed significantly as such f