Metabolism and disposition of hexachloro( 1,3)butadiene in rats
β Scribed by Reichert, D.
- Book ID
- 122901170
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 76 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0378-4274
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## Abstract The effect of a single i.p. dose of 200 or 300 mg kg^β1^ hexachloroβ1:3βbutadiene (HCBD) on liver morphology, water, sodium and potassium ion content, cation movement and nonβprotein sulphydryl (NPβSH) content has been studied in rats. There was a rapid, doseβrelated increase in liver w
Hexachloro-1,3-butadiene (HCBD) is more nephrotoxic to female than male rats. Metabolism of HCBD involves conjugation with glutathione followed by formation of the cysteine conjugate S-(pentachloro-1,3-butadienyl) cysteine (PCBD-CYS) and then the mercapturic acid N-acetyl-S-pentachloro-1,3-butadieny