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Metabolism and Disposition Kinetics of Nicotine

โœ Scribed by Hukkanen, J.

Book ID
125835443
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2005
Tongue
English
Weight
835 KB
Volume
57
Category
Article
ISSN
0031-6997

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Disposition kinetics of nicotine and cot
Disposition kinetics of nicotine and cotinine enantiomers in rabbits and beagle dogs
โœ Peyton Jacob III; Neal L. Benowitz; James R. Copeland; Marcus E. Risner; Edward ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 573 KB

The disposition kinetics of nicotine and cotinine enantiomers was determined in rabbits. The clearance of (R)-nicotine was similar to that of (S)-nicotine, but clearance of (R)-cotinine was twice that of (S)-cotinine. Fractional conversions of both enantiomers of nicotine to cotinine were approximat