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METABOLISM AND ABSORPTION OF l-3,4 DIHYDROXYPHENYLALANINE IN PATIENTS WITH PARKINSON'S DISEASE

✍ Scribed by Joseph R. Bianchine; Leonor R. Calimlim; John P. Morgan; Carlos A. Dujuvne; Louis Lasagna


Book ID
114879543
Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
756 KB
Volume
179
Category
Article
ISSN
0890-6564

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A double-blind, placebo-controlled, crossover trial of tolcapone (RO 40-7592), a potent reversible inhibitor of catechol-0-methyltransferase (COMT), was performed in 10 Parkinson's disease (PD) patients to determine single-dose safety and efficacy. All subjects were chronically treated with stable d