Metabolic Profiling of Human Lung Cancer Tissue by 1 H High Resolution Magic Angle Spinning (HRMAS) NMR Spectroscopy
✍ Scribed by Rocha, Cláudia M.; Barros, António S.; Gil, Ana M.; Goodfellow, Brian J.; Humpfer, Eberhard; Spraul, Manfred; Carreira, Isabel M.; Melo, Joana B.; Bernardo, João; Gomes, Ana; Sousa, Vitor; Carvalho, Lina; Duarte, Iola F.
- Book ID
- 127304078
- Publisher
- American Chemical Society
- Year
- 2010
- Tongue
- English
- Weight
- 767 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1535-3893
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## Abstract It is shown that high‐resolution ^1^H NMR spectra of intact excised tissues and organs can be obtained by rotating the sample slowly about an axis at the magic angle of 54°44′ with the external magnetic field. In this way tissue and cellular damage invoked by standard magic angle spinni
## Abstract High‐resolution magic angle spinning (HRMAS) ^1^H NMR spectroscopy is ideal for monitoring the metabolic environment within tissues, particularly when spectra are weighted by physical properties such as __T__~1~ and __T__~2~ relaxation times and apparent diffusion coefficients (ADCs). I