## Abstract Proton high‐resolution magic angle spinning (^1^H HR‐MAS) NMR spectroscopy and quantitative histopathology were performed on the same 54 MRI/3D‐MRSI‐targeted postsurgical prostate tissue samples. Presurgical MRI/3D‐MRSI targeted healthy and malignant prostate tissues with an accuracy of
✦ LIBER ✦
Metabolic, pathologic, and genetic analysis of prostate tissues: quantitative evaluation of histopathologic and mRNA integrity after HR-MAS spectroscopy
✍ Scribed by Carissa F. Santos; John Kurhanewicz; Z. Laura Tabatabai; Jeffry P. Simko; Kayvan R. Keshari; Akpene Gbegnon; Romelyn DeLos Santos; Scot Federman; Katsuto Shinohara; Peter R. Carroll; Christopher M. Haqq; Mark G. Swanson
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 254 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0952-3480
- DOI
- 10.1002/nbm.1474
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## Abstract The goal of this study was to investigate the use of lactate and alanine as metabolic biomarkers of prostate cancer using ^1^H high‐resolution magic angle spinning (HR‐MAS) spectroscopy of snap‐frozen transrectal ultrasound (TRUS)‐guided prostate biopsy tissues. A long‐echo‐time rotor‐s