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Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells

✍ Scribed by RobertV Blackburn; DouglasR Spitz; Xin Liu; SandraS Galoforo; JuliaE Sim; LisaA Ridnour; JennC Chen; BruceH Davis; PeterM Corry; YongJ Lee

Book ID: 114277065
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 429 KB
Volume: 26
Category: Article
ISSN: 0891-5849
DOI: 10.1016/s0891-5849(98)00217-2

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## Abstract Overexpression of catalase, but not manganese superoxide dismutase (MnSOD), inhibited glucose deprivation‐induced cytotoxicity and c‐Jun N‐terminal kinase 1 (JNK1) activation in human prostate adenocarcinoma DU‐145 cells. Suppression of JNK1 activation by catalase overexpression resulte