Metabolic labeling of human cells with tritiated nucleosides results in activation of the ATM-dependent p53 signaling pathway and acceleration of DNA repair

Indole-3-carbinol activates the ATM sign

Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells

✍ Christine T. Brew; Ida Aronchik; Jocelyn C. Hsu; Joon-Ho Sheen; Robert B. Dickso 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 968 KB

## Abstract The phytochemical indole‐3‐carbinol (I3C), from cruciferous vegetables such as broccoli, has been shown to elicit a potent anti‐proliferative response in human breast cancer cell lines. Treatment of the immortalized human mammary epithelial cell line MCF10A with I3C induced a G1 cell cy