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Metabolic flux profiling of HepG2–C3A cells

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
41 KB
Volume
107
Category
Article
ISSN
0006-3592

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✦ Synopsis

The discovery of antimicrobial peptides (AMPs)-which disturb the structure of bacterial membranes essential for an invading microorganism's existence-has increased our expectations for effective therapies against multi-drug resistant pathogens. A number of studies to investigate the relationship between structural factors and activity of AMPs to improve antimicrobial activity have been performed. However, interrelationships between various factors make it difficult to understand the leverage of a specific factor. In their article, Kim and Cha design model AMPs and compare their antimicrobial activities to assess the influence of a new factor, cationic dispersity, on the secondary structure of AMPs by application of a facile fluorescence-based activity assay method. This work can provide a clue for rational design of AMPs with enhanced activity. Furthermore, synergistic elevation of AMP activity can be possible by optimization of various combined factors.

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