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Metabolic Engineering for Microbial Production of Aromatic Amino Acids and Derived Compounds

✍ Scribed by Johannes Bongaerts; Marco Krämer; Ulrike Müller; Leon Raeven; Marcel Wubbolts

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
652 KB
Volume
3
Category
Article
ISSN
1096-7176

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✦ Synopsis

Metabolic engineering to design and construct microorganisms suitable for the production of aromatic amino acids and derivatives thereof requires control of a complicated network of metabolic reactions that partly act in parallel and frequently are in rapid equilibrium. Engineering the regulatory circuits, the uptake of carbon, the glycolytic pathway, the pentose phosphate pathway, and the common aromatic amino acid pathway as well as amino acid importers and exporters that have all been targeted to effect higher productivities of these compounds are discussed.

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