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Metabolic conversion of retinol to retinoic acid mediates the biological responsiveness of human mammary epithelial cells to retinol

✍ Scribed by Leslie J. Hayden; Susan N. Hawk; Tracey R. Sih; Michael A. Satre

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 265 KB
Volume: 186
Category: Article
ISSN: 0021-9541
DOI: 10.1002/1097-4652(2000)9999:999<000::aid-jcp1043>3.0.co;2-5

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BACKGROUND: Derivatives of retinol (vitamin A), commonly referred to as retinoids, signal through retinoic acid and retinoid X receptors (RARs/RXRs) and are essential for normal limb formation. Retinoid imbalances or perturbations in receptor function result in aberrant limb development. To examine