Metabolic control analysis : Sensitivity of control coefficients to elasticities
β Scribed by J. Rankin SMALL; David A. FELL
- Book ID
- 115128016
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 934 KB
- Volume
- 191
- Category
- Article
- ISSN
- 1432-1327
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A central quantity for the analysis of the interdependence of control coefficients is the Jacobian H of the pathway. For a simple metabolic chain, H is known to be tridiagonal. Its inverse H-1, which is required to calculate control coefficients, is semi-separable. A semi-separable nxn matrix (aij)
The sign of a flux (concentration) control coefficient of an enzyme determines if the metabolic flux (metabolite concentration) will increase or decrease when the enzyme concentration is increased/decreased. In general, the sign of a control coefficient depends on the magnitudes of the enzyme elasti