𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Metabolic control analysis : Sensitivity of control coefficients to elasticities

✍ Scribed by J. Rankin SMALL; David A. FELL


Book ID
115128016
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
934 KB
Volume
191
Category
Article
ISSN
1432-1327

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A central quantity for the analysis of the interdependence of control coefficients is the Jacobian H of the pathway. For a simple metabolic chain, H is known to be tridiagonal. Its inverse H-1, which is required to calculate control coefficients, is semi-separable. A semi-separable nxn matrix (aij)

On the Sign Pattern of Metabolic Control
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The sign of a flux (concentration) control coefficient of an enzyme determines if the metabolic flux (metabolite concentration) will increase or decrease when the enzyme concentration is increased/decreased. In general, the sign of a control coefficient depends on the magnitudes of the enzyme elasti