Metabolic control analysis of relaxation processes
β Scribed by Reinhart Heinrich; Christine Reder
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 407 KB
- Volume
- 151
- Category
- Article
- ISSN
- 0022-5193
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π SIMILAR VOLUMES
Based on a simplified model of a linear metabolic pathway (Kacser & Burns, 1973), and on the principles of Metabolic Control Analysis, an equation useful for predicting the maximum flux through a system after removing inhibitory feedback interaction is presented. The analysis shows that only when th
Mathematical description of metabolic systems allows the calculation of the expected responses of metabolism to genetic modifications and the identification of the most promising targets for metabolic engineering. Metabolic control analysis (MCA) provides such a description in the form of quantitati
In the top down approach to metabolic control analysis, reactions are grouped together into a few large blocks connected by a small number of intermediates. Control is analysed by adding inhibitors or activators that work within single blocks and measuring intermediates and fluxes, or by adding new