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Metabolic consequence of long-term exposure of pancreatic β cells to free fatty acid with special reference to glucose insensitivity

✍ Scribed by Katsumi Iizuka; Hiromu Nakajima; Mitsuyoshi Namba; Jun-ichiro Miyagawa; Junichi Miyazaki; Toshiaki Hanafusa; Yuji Matsuzawa

Book ID: 117617848
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 306 KB
Volume: 1586
Category: Article
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(01)00082-5

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## Abstract Pancreatic β‐cells metabolise both lipid and glucose nutrients but chronic exposure (>24 h) to elevated fatty acid (FA) concentrations results in deleterious metabolic and morphological changes. The aims of this study were to assess the adaptive morphological, metabolic and secretory re