𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Metabolic changes in the rat brain after acute and chronic ethanol intoxication: A 31P NMR spectroscopy study

✍ Scribed by R. Denays; S. L. Chao; R. Mathur-Devré; O. Jeghers; J. Frühling; P. Noël; H. R. Ham

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
543 KB
Volume
29
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In this work, ^31^P phosphorus NMR (^31^P NMR) studies of the brain have been conducted in rats acutely and chronically intoxicated with ethanol. In both groups, changes in levels of high‐energy phosphates were observed: increase of phosphocreatinine (PCr)/β AaTP and PCr/inorganic phosphate (P~i~) in acute and long‐term ethanol exposure, and decrease of P~i~β ATP after acute ethanol administration. These changes in high‐energy phosphates, indicative of a reduction of adenosine triphosphate (ATP) and PCr consumption (PCr+ ADP + H^+^ ATP + Cr; ATP ADP + P~i~), suggest a reduction of cerebral metabolism both in acute and chronic ethanol exposure. In addition, in the group of rats chronically intoxicated with ethanol, there were variations in phosphodiester peak intensities (decrease of phosphomonoester (PME)/phosphodiester (PDE), increase of PDE/β ATP), suggesting increased breakdown of membrane phospholipids. These changes could provide a metabolic explanation for the development of cerebral atrophy in chronic alcoholism.

📜 SIMILAR VOLUMES

The effects of chronic ethanol consumpti
The effects of chronic ethanol consumption on the intact rat liver studied by in vivo31P NMR spectroscopy
✍ Manfred Brauer; Mingfu Ling 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 734 KB

## Abstract __In vivo__ ^31^P nuclear magnetic resonance (NMR) spectroscopy provides unique opportunities to study the biochemistry of an organ within the intact animal in a totally noninvasive way. We have used __in vivo__ and __in vitro__ ^31^P NMR spectroscopy to study steady state changes in th

Hypoxic cell cytotoxin tirapazamine indu
Hypoxic cell cytotoxin tirapazamine induces acute changes in tumor energy metabolism and pH: A 31p magnetic resonance spectroscopy study
✍ Eric O. Aboagye; Larry E. Dillehay; Zaver M. Bhujwalla; Ding-Jen Lee 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB 👁 2 views

Tirapazamine is a hypoxic cell cytotoxin in phase II/III trials. To further understand its mechanism of action in vivo, we examined the effect of tirapazamine on tumor energy metabolism and pH. RIF-1 and SCCVII tumors were grown subcutaneously in the flanks of C3H mice. Tumor energy metabolism, expr

31P NMR study of cisplatin- and doxorubi
31P NMR study of cisplatin- and doxorubicininduced changes in tumour metabolism in rats with a cisplatin-sensitive or -resistant immunocytoma
✍ P. E. Sijens; C. J. A. van Echteld; R. H. van Rijssel; J. J. W. Lagendijk; J. P. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 887 KB

## Abstract The response of tumours to treatment with the cytostatic drugs cisplatin (CDDP) or doxorubicin (DXR) was followed __in vivo__ by ^31^P NMR spectroscopy. A CDDP‐sensitive parent line (IgM‐I) and a CDDP‐resistant subline (IgM/CDDP) of the IgM‐immunocytoma grown s.c. on LOU/M WsL rats were