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Metabolic and nutritional implications of valproic acid

✍ Scribed by Nurge, Michelle E.; Anderson, Christine R.; Bates, Edric


Book ID
121984760
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
831 KB
Volume
11
Category
Article
ISSN
0271-5317

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The role of metabolites in valproic acid (VPA)-associated hepatotoxicity was studied in rats. The most steatogenic mono-unsaturated metabolite, 4-en-VPA, caused the greatest changes in indicators of beta-oxidation inhibition (dicarboxylic aciduria, beta-hydroxybutyrate reduction); however, the bioch