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Metabolic Alterations During the Growth of Tumour Spheroids

✍ Scribed by Bloch, Katarzyna; Smith, Hannah; Hamel Parsons, Victoria; Gavaghan, David; Kelly, Catherine; Fletcher, Alexander; Maini, Philip; Callaghan, Richard

Book ID
125376799
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
588 KB
Volume
68
Category
Article
ISSN
1085-9195

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Mammalian cells growing as multicell spheroids, an in vitro model of tumor microregions, have been shown previously to be more resistant than single cells from monolayer cultures to killing by ionizing radiation, hyperthermia, ultrasound, and chemotherapeutic drugs. Although the mechanisms by which