METABOLIC ACTIVITY OF CNS PROTEINS IN RATS AND MONKEYS WITH EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS (EAE)
β Scribed by Marion Edmonds Smith; Helene C. Rauch
- Book ID
- 111167562
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 698 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-3042
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Studies from our laboratory have shown that classical clinical and histological signs of experimental allergic encephalomyelitis (EAE) may be induced in Lewis rats by synthetic peptides S49 or S55. Peptides S49S and S55S are defined by residues 69-84 and 72-84 of the guinea pig myelin basic protein
## Abstract Mononuclear cell infiltration into the CNS and induction of inflammatory cytokines and iNOS in diseases like multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE) have been implicated in subsequent disease pathogenesis and progression. We report that Lovastatin treat