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Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay

✍ Scribed by Naoya Hatanaka; Hiroshi Yamazaki; Yoshimitsu Oda; F.Peter Guengerich; Miki Nakajima; Tsuyoshi Yokoi

Book ID: 117766800
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 199 KB
Volume: 497
Category: Article
ISSN: 1383-5718
DOI: 10.1016/s1383-5718(01)00254-6

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## Abstract The worldwide human exposure to aflatoxin B~1~ (AFB~1~), particularly in developing countries, remains to be a serious public health concern. Although AFB~1~ is best known as a hepatocarcinogen, epidemiological studies have shown a positive association between human lung cancer occurren