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Metabolic activation of 2,6-diaminopurine and 2,6-diaminopurine-2′-deoxyriboside to antitumor agents

✍ Scribed by Gisbert Weckbecker; Joseph G. Cory

Book ID
118372110
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
995 KB
Volume
28
Category
Article
ISSN
0065-2571

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✍ Wallis, Cheryl ;Wilkie, David 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 694 KB

2,6-diaminpurine (DAP) selectively inhibited mitochondrial protein synthesis in yeast cells with concomitant failure of cells to grow in non-fermentable (yeast extract, glycerol) medium. The selectivity was pronounced in all strains tested (15) nearly all of which were able to grow in yeast extract,