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Metabolic activation capabilities of S9 liver fraction from 3 species in the L5178Y mouse-lymphoma assay

โœ Scribed by T.J. Oberly; C.E. Piper; D.S. McDonald


Book ID
113254278
Publisher
Elsevier Science
Year
1982
Weight
284 KB
Volume
105
Category
Article
ISSN
0165-7992

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In previously described activation systems [Clive D, Spector : Mutat Res 31:17-291 for the mouse lymphoma mutation assay the cofactor isocitrate is rapidly exhausted and the resultant loss of NADPH can halt metabolic processes. Presented here are data obtained with a nontoxic b'olance of NADP (1.4 m