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Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia

โœ Scribed by Yuki Kobayashi; Tatsuki Fukami; Ryota Higuchi; Miki Nakajima; Tsuyoshi Yokoi

Book ID
119194837
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
942 KB
Volume
84
Category
Article
ISSN
0006-2952

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## Abstract CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. PAHs can induce the activity of both enzymes, which increases its conversion and enhances risk of carcinogenesis. Thus, the inhibition of CYP enzymes is recognized as a cancer ch