Metabolic acidosis in patients receiving anticonvulsants

✍ Scribed by Bunsaku Nagai; Ichiro Matsuda; Takahito Kondo; Naoyuki Taniguchi; Shinichiro Arashima; Takashi Mitsuyama; Yogo Oka; Masakatsu Honma

• Book ID: 104775844
• Publisher: Springer
• Year: 1979
• Tongue: English
• Weight: 366 KB
• Volume: 132
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00442432

✦ Synopsis

Blood pH, bicarbonate, PCO2, serum calcium, alkaline phosphatase and red cell carbonic anhydrase were measured in 37 selected patients receiving anticonvulsants. Patients with metabolic acidosis showed a high incidence of hypocalcemia with increased alkaline phosphatase and a significant reduction of carbonic anhydrase-B activity. High iPTH levels were found in 13 patients, but this was not correlated with acid-base balance status. Anticonvulsant drugs seemed to inactive carbonic anhydrase-B activity. Metabolic acidosis might be one of the factors causing a disturbance of calcium metabolism in these patients.