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Meta-analysis—its role in assessing drug safety

✍ Scribed by David Henry; Susan Hill

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
121 KB
Volume
8
Category
Article
ISSN
1053-8569

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✦ Synopsis

Randomized controlled clinical trials (RCTs) usually aim to demonstrate the ecacy of drugs under a speci®ed set of conditions. Trials are designed to meet the needs of sponsors, regulators, and to some degree investigators. They are often poorly designed to meet the needs of prescribers and consumers of modern medications. In part, this is because a trial designed to demonstrate ecacy, in an ecient manner, may not provide satisfactory information on the overall balance of bene®t and harm. In particular, there is likely to be inadequate information on the adverse outcomes of treatment with the new medication. 1 With drugs

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