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Meta-analysis of hypertension treatment trials

✍ Scribed by Cruickshank, J.M.; Fox, K.; Collins, P.; Alderman, MichaelH.; Kaplan, NormanM.; Jenkinson, M.L.


Book ID
122052619
Publisher
The Lancet
Year
1990
Tongue
English
Weight
485 KB
Volume
335
Category
Article
ISSN
0140-6736

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Exploration of the variation of treatment effect over time in randomized clinical trials with low event rates is limited by lack of power. A meta-analysis on individual patient data from such trials can partly solve the problem, but brings other computational difficulties. Using an example in hypert