Meta-analysis of genome-wide linkage studies for bone mineral density
β Scribed by Young Ho Lee; Young Hee Rho; Seong Jae Choi; Jong Dae Ji; Gwan Gyu Song
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 227 KB
- Volume
- 51
- Category
- Article
- ISSN
- 1435-232X
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Meta-analysis of genome-wide association studies involves testing single nucleotide polymorphisms (SNPs) using summary statistics that are weighted sums of site-specific score or Wald statistics. This approach avoids having to pool individual-level data. We describe the weights that maximize the pow
## Abstract Genomeβwide association studies have recently identified many new loci associated with human complex diseases. These newly discovered variants typically have weak effects requiring studies with large numbers of individuals to achieve the statistical power necessary to identify them. Lik