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Meta-analysis of genetic variability in the β-amyloid production, aggregation and degradation metabolic pathways and the risk of Alzheimer’s disease

✍ Scribed by J. Llorca; E. Rodríguez-Rodríguez; T. Dierssen-Sotos; M. Delgado-Rodríguez; J. Berciano; O. Combarros

Book ID
109338669
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
195 KB
Volume
0
Category
Article
ISSN
0001-6314

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## Abstract The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), which is subsequently cleaved by γ‐secretase to produce Aβ. Our previous studies have shown that the proteas