Meta-analysis: inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease
β Scribed by J. M. VAN DIEREN; B. E. HANSEN; E. J. KUIPERS; E. E. S. NIEUWENHUIS; C. J. VAN DER WOUDE
- Book ID
- 108605042
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 776 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0269-2813
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## Background: Thr300ala polymorphism in atg16l1 was reported as a susceptibility factor to crohn's disease (cd). inconsistently replicated associations with ulcerative colitis (uc) and specifically with ileal cd were also reported. our aims were: to replicate the atg16l1 thr300ala association with
Background: Thiopurine drugs are widely used in the treatment of inflammatory bowel disease (IBD). The polymorphic enzyme thiopurine S-methyltransferase (TPMT) is of importance for thiopurine metabolism and adverse events occurrence. The role of other thiopurine-metabolizing enzymes is less well kno