Met decoys: Will cancer take the bait?

The polyphenol epigallocatechin-3-gallat

The polyphenol epigallocatechin-3-gallate affects lipid rafts to block activation of the c-Met receptor in prostate cancer cells

✍ Damian Duhon; Rebecca L. H. Bigelow; David T. Coleman; Joshua J. Steffan; Chris 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 512 KB

The HGF/c-Met pathway is an important regulator of signaling pathways responsible for invasion and metastasis of most human cancers, including prostate cancer. Exposure of DU145 prostate tumor cells to HGF stimulates the PI3-kinase and MAPK pathways, leading to increased scattering, motility, and in