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Mesoporous silica nanoparticles: importance of surface modifications and its role in drug delivery

✍ Scribed by Natarajan, Siva Kumar; Selvaraj, Stalin

Book ID: 121698059
Publisher: The Royal Society of Chemistry
Year: 2014
Tongue: English
Weight: 649 KB
Volume: 4
Category: Article
ISSN: 2046-2069
DOI: 10.1039/c4ra00781f

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## Abstract Targeted delivery of the chemotherapeutic agent methotrexate (MTX) to cancer cells using poly(ethyleneimine)‐functionalized mesoporous silica particles as drug‐delivery vectors is reported. Due to its high affinity for folate receptors, the expression of which is elevated in cancer cell