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Mesenchymal stem cells are sensitive to treatment with kinase inhibitors and ionizing radiation

✍ Scribed by Nicolay, Nils H.; Sommer, Eva; Perez, Ramon Lopez; Wirkner, Ute; Bostel, Tilman; Ho, Anthony D.; Lahn, Michael; Debus, Jürgen; Saffrich, Rainer; Huber, Peter E.

Book ID
125339036
Publisher
Springer
Year
2014
Tongue
German
Weight
581 KB
Volume
190
Category
Article
ISSN
0179-7158

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ATM and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) have been shown to have sequences homologous to the catalytic domains of mammalian phosphatidylinositol 3-kinase (PI3-kinase). In order to determine the contribution of ATM and DNA-PKcs to the increased sensitivity of cells to DNA-dam