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Mesenchymal stem cell therapy increases proinflammatory cytokine production via NFkB activation independent of the PI3 kinase pathway

✍ Scribed by Peter A. Walker; Matthew T. Harting; Fernando Jimenez; Shibani Pati; Pramod Dash; Charles S. Cox Jr

Book ID: 113679396
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 93 KB
Volume: 209
Category: Article
ISSN: 1072-7515
DOI: 10.1016/j.jamcollsurg.2009.06.211

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi