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Merlin and the ERM proteins in Schwann cells, neurons and growth cones

✍ Scribed by Ramesh, Vijaya


Book ID
109961799
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
405 KB
Volume
5
Category
Article
ISSN
1471-0048

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Neurofibromatosis type 2, a disease characterized by the formation of multiple nervous system tumors, especially schwannomas, is caused by mutation in the gene-encoding merlin/schwannomin. The molecular mechanism by which merlin functions as a tumor suppressor is unknown, but is hypothesized to invo