Meperidine and normeperidine convulsions in mice: Possible opiate and serotonergic mechanisms

✍ Scribed by Steven Roy Bader; Dr. Paul A. Moore

• Book ID: 102139876
• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 366 KB
• Volume: 3
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.430030411

✦ Synopsis

The effects of naloxone and 5-hydroxytryptophan (5-HTP) pretreatment on convulsions induced by meperidine and normeperidine were studied in male Swiss-Webster mice. The CD50 (95% confidence limits) was found to be 17.5 mg/kg (15.6-19.6) for meperidine and 38.0 mglkg (36.2-39.9) for normeperidine administered intravenously. Convulsions induced by meperidine (17.5 mg/kg) were significantly attenuated by naloxone (30 mglkg) pretreatment but not by 5-HTP pretreatment alone. Normeperidine (38.0 mglkg) induced convulsions were significantly attenuated by 5-HTP pretreatment, but not by naxolone pretreatment. The administration of a combined dose of meperidine and normeperidine does not produce a supra-additive response.