Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback
β Scribed by Naomi E. Rance
- Book ID
- 116831682
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 937 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0196-9781
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In situ hybridization histochemistry was used to map the distribution of neurons expressing the substance P (SP) or neurokinin B (NKB) genes in the human hypothalamus and basal forebrain. Hypothalami from five adult males were frozen in isopentane at 230Β°C and serially sectioned at 20 Β΅m thickness.
It is becoming increasingly clear that the neuropeptide cholecystokinin (CCK), widely distributed in the rat hypothalamus and limbic system, is subject to both organizational and activational influences of steroid hormones. Sex differences in numbers of CCK-immunoreactive elements have been demonstr